Glomeruli synthesize nitrite in experimental nephrotoxic nephritis
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چکیده
منابع مشابه
Nephrotoxic Nephritis in Rats
Nephrotoxic anti-rat kidney sera were produced in rabbits by intraperitoneal injection of suspensions of blood-free rat kidney. The nephrotoxin of these sera could be removed by adsorption with saline suspensions of finely ground rat glomeruli, but not by adsorption with other portions of rat kidney or by adsorption with several other rat tissues. It was concluded that nephrotoxic sera of this ...
متن کاملNephrotoxic Serum Nephritis in Rats
Studies have been carried out to determine the distribution of antigen capable of inducing the formation in rabbits of antibodies nephrotoxic for the rat. The results indicate that the antigen is present both in cortex and medulla of rat kidney. It can be extracted to a limited extent with saline. It is non-dialyzable and destroyed by boiling. The nephrotoxic serum antigen is also present in ra...
متن کاملChronic nephrotoxic nephritis in spontaneously hypertensive rats.
(NTS) in Wistar rats (WR) and spontaneously hypertensive rats (SHR), our previous results suggested that sustained hypertension might aggravate the nephrotoxic processes or protract the course of glomerulonephritis. The present study was attemped to observe the more prolonged glomerular changes of nephrotoxic nephritis (NTN) until 15 weeks after the injection of NTS in SHR, compared with contro...
متن کاملThe Mechanism by Which Experimental Nephritis Is Produced in Rabbits Injected with Nephrotoxic Duck Serum
1. Glomerulonephritis was produced in rabbits by the injection of antirabbit-kidney duck serum. 2. The clinical and pathologic characteristics of the disease are discussed. 3. It was found possible by appropriate means either to accelerate the development of the nephritis or to prevent its appearance entirely. 4. An apparent correlation was found between the development of the nephritis and the...
متن کاملInterleukin-11 attenuates nephrotoxic nephritis in Wistar Kyoto rats.
Interleukin-11 (IL-11) is a multifuctional cytokine with anti-inflammatory activity. The effect of IL-11 was studied in an experimental model of necrotizing glomerulonephritis induced in Wistar Kyoto rats by an injection of anti-glomerular basement membrane antibody (nephrotoxic serum). Intraperitoneal injection was chosen as the route of IL-11 administration in all experiments. In experiment 1...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1990
ISSN: 0085-2538
DOI: 10.1038/ki.1990.312